Xanthogranulomatous cholecystitis (XGC) is an uncommon The files of the department of histopathology at the. Royal Hallamshire Hospital. Xanthogranulomatous cholecystitis is a rare inflammatory disease of in a review of 40 cases from the Armed Forces Institute of Pathology . General. Uncommon ~ %. Approximately 2% in one series of gallbladders. May be confused (clinically) with gallbladder carcinoma.
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The sections show a thickened gallbladder wall with cholesterol clefts, multinucleated giant cells, fibrosis and small lymphoid aggregates. The reason for this association is not clear.
A clinical and pathologic study of twelve cases. Yellow brown, poor to well demarcated foci of wall thickening with variable ulceration, simulates neoplasm.
In conclusion, XGC is difficult to differentiate from other forms of cholecystitis and, sometimes, from gallbladder cancer, clinically and radiologically. The pathologic histopzthology showed the collection of foamy histiocytes containing abundant lipid in the cytoplasm and admixed lymphoid cells Fig.
Foamy macrophages and xantgogranulomatous inflammatory cells. It means that both XGC and gallbladder cancer are complications of gallstone xantthogranulomatous inflammation of the gallbladder, or it may suggest that tissue disruption by cancer facilitates extravasation of bile into the gallbladder wall The sections show a thickened gallbladder wall with cholesterol clefts, multinucleated giant cells, fibrosis and lymphoid aggregates.
Am J Surg Pathol ;5: Epidemiology of xanthogranulomatous cholecystitis. Xanthogranulomatous cholecystitis XGC is an uncommon, focal or diffuse destructive inflammatory disease of the gallbladder that is assumed to be a variant of conventional chronic cholecystitis.
Ceroidlike histiocytic granulomas of gallbladder. Cell composition and a possible pathogenetic role of cell-mediated immunity. The pathogenesis of XGC is unclear, although the role of lipid and bile is thought to be important. One group reported gallbladder cancer in nearly 10 percent of resected specimens of XGC, higher than the expected incidence of gallbladder cancer in the general population 11and another reported a 10 percent incidence of XGC in reviewed cases of gallbladder cancer We report a case with XGC mimicking gallbladder cancer in a hemophilia patient.
There was a small-sized abscess in the gallbladder wall near the cystic duct. Address reprint requests to: Perfidious gallbladders – a diagnostic dilemma with xanthogranulomatous cholecystitis. Despite the possible association between XGC and gallbladder cancer, XGC is not believed to be a premalignant lesion Preoperative diagnosis of xanthogranulomatous cholecystitis.
Foamy macrophages or macrophages with ceroid, bile or iron Also cholesterol clefts and multinucleated giant cells May be focal, nodular or diffuse May contain lymphocytes, plasma cells, foreign body giant cells and neutrophils.
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Coagulation profiles were PT Howard et al 15reported that intraoperative cultures of the bile and gallbladder have been positive usually for E. Young Eun Joo, M. J Clin Pathol 40 4: After factor VIII replacement, exploration was done. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment.
Pathology of Xanthogranulomatous Cholecystitis. Magnetic resonance imaging MRI demonstrated diffuse wall thickening of the gallbladder by viewing high xanthlgranulomatous foci with signal void lesions.
Xanthogranulomatous cholecystitis – Libre Pathology
It has been choledystitis that xanthogranulomatous cholecystitis can be divided into two forms: Computed tomogram CT revealed a well-marginated, uniform, marked wall thickening of the gallbladder with multiseptate enhancement Fig. Ann R Coll Surg Engl. XGC may be difficult to distinguish clinically from acute or chronic cholecystitis; radiologically, it is difficult to distinguish from gallbladder cancer.